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Questions for Discussion: Synthesizing an Alkaloid
- Why was determining the melting point of a substance so important in the story of the synthesis of physostigmine?
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What technique did Julian use to determine the melting point of the substance he had synthesized?
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Explain how the ratio of carbon, hydrogen, and oxygen in a substance can help you identify an organic substance.
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Why do you think the position of the methyl groups was an important feature of physostigmine?
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Can you see any similarities between what Julian did in his synthesis and, say, the baking of a cake? Does it matter what order the steps come in the process?
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Using evidence from this video, would you say that scientists cooperate or compete with each other? What role does publication of scientific findings play in the progress of
scientific understanding?